Saturday, November 30, 2019

Value and Risk Management in construction UAE

An Evaluation of Current and Potential Future Application of Value and Risk Management into Construction Project Management Professional Services in the Construction Sector in the UAEAdvertising We will write a custom essay sample on Value and Risk Management in construction UAE specifically for you for only $16.05 $11/page Learn More Abstract: The UAE had an unprecedented boom in its construction sector between 2004 and 2008. This ended during the international financial crisis of 2008. As a result, the UAE Prime Minister issued a decree requiring all contractors to use green principles in construction projects. The high-end construction market responded by adopting stronger VRM practices. The state of VRM in the UAE is that it is growing in prominence. However, the professionals in the area are very few. In many cases, external consultants provide VRM services. The future of VRM in the UAE requires better training for undergraduate engineers, to supple ment the efforts of the existing postgraduate VRM professionals. General Structure of the Paper This paper has two main sections. The paper includes a literature review covering the essential background of both value management and risk management, and the result of the combination of the two, into value and risk management. The paper also presents the findings of a survey conducted to determine the VRM awareness levels of professionals in the construction sector in the UAE. The paper concludes by presenting the conclusions obtained in answer to the problem statement. Introduction The UAE is a regional leader in the application of VRM principles. This paper seeks to examine the issues that have an impact on VRM practices in the UAE and the implications of these issues for the future. The period between 2004 and 2008 will remain etched in the memory of the UAE as the heyday of the construction industry. In that time, value management did not command much respect because investors in the construction sector did not demand efficiency in their projects. They favored fast pace construction over cost management. The result of this attitude is that the UAE is now home to some of the most energy intensive skyscrapers in the world. Value and risk management is slowly finding its place in the construction sector. The rules have changed. It is no longer survival for the swiftest in the UAE, but survival of the fittest. This article examines the current state and future opportunities of value management in the UAE.Advertising Looking for essay on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More VRM in the UAE In any business, value comes from business processes. The professional process of ensuring that a certain process yields maximum value for the stakeholder at the least cost is value management . The definition of value in this case is not just the financial value. Rather it is value in the context of the ba lanced scorecard, which covers the financial value, value from internal processes, value for the customer in question, and value in terms of transferable experience for the contractor . On the other hand, risk management is an active process of finding potential events or circumstances that can affect the progress of a project if they take place during the life of the project . The occurrence of risk must be uncertain. Otherwise, the event ceases to be a risk. Risks associated with the construction sector range from material defects to industrial action by workers. The cost of many construction projects is very high. This creates the need to manage risks as effectively as possible. Risk management involves the identification of potential events that will trigger the risk and determining the probability of occurrence of that event. After that, the risk manager quantifies the impact of the occurrence of risk-causing event on the project in terms of loss of life, time, money, and busin ess opportunities. It is possible to view risk management as a specialized form of value management because risk can erode the value of a project. It serves a preventative purpose. Value management on the other hand aims at increasing value from the processes by reducing costs or increasing the utility of the outcomes of the project . According to Karim, Berawi, Yahya, Abdul-Rahman, and Mohamed (2007) the value management process has three stages namely, value planning, value engineering and value analysis. Value planning takes place during the planning phase of the project. Value engineering occurs during construction, while value analysis takes place after the construction phase. Value analysis helps in the establishment of measures to ensure that the value gained during the value engineering process lasts throughout the useful life of the building. The risk management process involves risk identification, analysis, response, and monitoring . Risk identification and analysis take place during the planning of the project at the same time as value planning. Risk monitoring takes place throughout the active life of the project. The construction teams use risk indicators to monitor the risks. Risk response depends on whether the risk events take place or not. If a risk occurs, risk response takes place. The amalgamation of risk management (RM) and value management (VM) into risk and value management (RVM) comes from the relative similarity of the objectives of these two aspects of construction management. Focusing on RM only can erode value while focusing on VM only can introduce high risks to the project .Advertising We will write a custom essay sample on Value and Risk Management in construction UAE specifically for you for only $16.05 $11/page Learn More The rising stature of VRM in the UAE is as a direct result of the events that took place between 2004 and 2008 in the construction sector . In 2004, the construction sector in th e UAE was experiencing unprecedented growth. The country was on the path to achieve its dream of becoming a transport, trade, and commercial hub in the Middle East . This led to an increase in the number of the immigrants looking for work in the Emirates. In addition, many traders were coming to the UAE to close business deals. The result was that the demand for housing and commercial buildings grew. The country saw the construction of an unprecedented number of new buildings to meet the rising demand. Since investment funds were flowing, the speed of construction became the driving force. VM was not central to project planning in the construction industry. The UAE ended up undertaking projects that delivered buildings with the highest energy consumption in the world . In 2008, the UAE economy went through a downturn occasioned by the global financial crisis triggered by the US real estate market . Since that year, there has been a growing appreciation of the role VM can play in the construction industry. The shift towards VM goes back to 2007 when Sheikh Mohammed bin Rashid Al Maktoum, the Prime Minister of the UAE, issued a decree that ordered players in the construction industry to conform to a newly established green standard in their projects . The decree took effect in January 2008 just when the global financial crisis was hitting the UAE. From that time, there has been a steady increase in the number of construction companies using VM in order to meet project goals and the regulatory goals. Evidence in literature suggests that the current state of application of VRM in the UAE is uncoordinated. While there is widespread recognition of the potential saving the use of VRM can bring to projects, the practice is not widespread. It appears that the planning processes of construction projects do not include VRM. A case in point is the low-income housing project in Musaffah, Abu Dhabi in which VRM principles were not part of the planning process . Some of the design choices made by the project planners seemed unsuited for the construction projects. For instance, the houses contained some utilities such as gas-powered central heating, which is not fitting for low-income housing . In addition, the water tanks positioned outside on the roofs of the houses started malfunctioning after three years, yet the project requirements stated that the life cycle for each house was to be twenty-five years . The main contention resulting from this situation is that project planners did not carry out VRM with the users of the house in mind.Advertising Looking for essay on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More Rather, the designers used uneconomical design options to raise their design fees since they charge a percentage of overall project cost. The current application of VRM in construction projects in the UAE is also a reflection of the little manpower available to conduct VRM. The VRM Survey Methodology A VRM survey conducted for this project revealed several issues regarding the current and future prospects of VRM in the UAE. The survey involved professionals working in the construction industry with decision-making responsibilities. Results The key findings of the survey were that only ten percent of the engineering professionals in the construction sector have any form of training in VRM, and none of the respondents have participated in a VM program. VM training in the UAE is available in postgraduate courses in construction management. The graduates do not all go to practice VRM hence the lack of involvement in any VRM project. The fact that most professional engineers in the UAE w ithout postgraduate qualifications have not formal training in VRM may indicate the low skill levels in the area of VRM in the country. Other findings in the survey showed that there is a general understanding of what RM is, but the views of respondents on VM did not demonstrate a strong grasp of the concept. When asked about their understanding of VM, most of the respondents used cost savings as the main issue in VM. The answers included phrases like, â€Å"help clients reduce costs†, â€Å"managing expenses in construction†, and â€Å"having the best quality with least money†. Forty percent of the respondents had no idea what VM meant. There seemed to be a perception that VM is part of project scope management because many responses included phrases talking about time, quality, and money. The responses for a similar question relating to RM showed a better understanding of RM in a project. RM is a core part of undergraduate construction courses hence it is not surprising that most of the respondents were articulate about RM. None of the respondents had any experience in analyzing the benefits of VRM exercise because none of them had participated in a VRM exercise. All the respondents felt that the application of VRM in the UAE should continue. The responses depended on their understanding of VRM in the first place. One respondent pointed out that VRM activities take place in large projects only. Therefore, there is a need to downstream the practice. Another respondent also added that the practice of VRM in the UAE is selective. The project managers choose to implement some elements and ignore others. This leads to low return from the VRM process, which requires implementations throughout the project cycle. Based on this survey, the need to make VRM conventional is obvious. If the professionals in the construction industry do not have a clear understanding of the basics of VRM, then the construction industry will not have people who can ch ampion for VRM. The best way to tackle this gap is to include VRM in the training curriculums of all construction courses. Even if this does not produce VRM consultants, it will empower these professionals to evaluate the benefits of VRM in construction projects. The current model where consultants carry out all VRM activities is not sustainable for nationwide impact. If project initiators do not want to spend money on consultants, a project does not benefit fully from VRM. Training all professionals in the industry to understand VRM will increase the appreciation and application of VRM in the industry. In conclusion, while the data available from industry sources such as The Oxford Business Group may suggest a vibrant VRM environment in the UAE, the data collected for this project shows that there are serious training gaps in VRM in the UAE. Industry publications are niche publications hence they may report in detail issues having an effect on a very small part of the overall envir onment. Conclusions The main conclusions from this project are as follows. VRM is increasing in importance in the UAE, partly because of intervention by the state, and partly because of the lessons learnt after the global financial crisis. The decree by Sheikh Mohammed bin Rashid Al Maktoum, the Prime Minister of the UAE that took effect in 2008 requires all construction projects to use green principles in construction. VRM is an essential part of ensuring all green projects meet the requirements of the decree. Secondly, there is inadequate capacity in the UAE to mainstream VRM across the construction sector. This conclusion comes from the survey conducted for the purposes of this project to find out the current level of manpower available to push forward the VRM agenda in the UAE. If UAE can train professionals at all levels, then it will improve the practice of VMR in the country. Thirdly, the Engineering Associations in the can play a part in mainstreaming VRM by conducting train ing seminars for all engineers working in the UAE. Currently the training levels of VRM are too advanced. Undergraduate engineers do not have the skills and experience needed to implement VRM in their settings. Finally, institutions of higher learning in the UAE need to include VRM as part of the coursework for all construction courses at undergraduate level. This will serve to increase the capacity of the country to make VRM a part of construction planning for all sizes of projects. References Abdellatif, MA Othman, AA 2008, ‘Improving the Sustainability of Low Income Housing Projects: The Case of Residential Buildings in Musaffah Commercial City in Abu Dhabi.’, Emirates Journal of Engineering, vol 11, no. 2, pp. 47-58. Davies, RH Davies, AJ 2011, Value Management: Translating Aspirations Into Performance, Gower Publishing, Surrey. Gordon, RJ 2012, ‘Is U.S. Economic Growth Over? Faltering Innovation Confronts the Six Headwinds NBER, vol 18315, pp. 1-23. Jaapar, A Torrance, JV 2010, ‘Contribution of Value Management to the Malaysian Construction Industry: A New Insight’, Faculty of Architecture, Planning Surveying, Universiti Teknologi MARA, Selangor Darul Ehsan. Karim, SBA, Berawi, MA, Yahya, IA, Abdul-Rahman, H Mohamed, O 2007, ‘The Integration of Value and Risk Management In Infrastructure Projects: Learning from Others’, Quantity Surveying International Conference., Value Management Centre (VMC), Faculty of the Built Environment, University of Malaya, Kuala Lumper. Koenig, M Meissner, J 2011, ‘Risk Minimizing Strategies for Revenue Management Problems with Target Values. ‘, Working Paper, Department of Management Science, Lancaster University Management School, Lancaster University Press, Lancaster. KPMG 2003, ‘Internal Audit’s Role in Modern Corporate Governance’, Risk and Advisory Services, KPMG, KPMG, Hong Kong. Meredeth, JR Mantel, SJ 2011, Project Management: A Manager ial Approach, 8th edn, John Wiley and Sons, Hoboken, NJ. Othman, AA 2005, ‘Value and Risk Management Protocol for Dynamic Brief Development in Construction’, Emirates Journal for Engineering Research, vol 10, no. 2, pp. 23-36. Othman, AA 2008, ‘Incorporating Value and Risk Managemen Concepts in Developing Low Cost Housing Projects ‘, Emirates Journal for Engineering Research, vol 13, no. 1, pp. 45-52. Siterman, E 2009, Value engineering in Dubai, https://www.constructionweekonline.com/article-6484-value-engineering-in-dubai#.UK-MnuR1-OH. The Oxford Business Group 2008, The Report: Dubai 2008, Oxford Business Group, Dubai. This essay on Value and Risk Management in construction UAE was written and submitted by user Giancarlo Russell to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Monday, November 25, 2019

The role of ApoE and its isoforms in Alzheimer’s disease The WritePass Journal

The role of ApoE and its isoforms in Alzheimer’s disease The role of ApoE and its isoforms in Alzheimer’s disease IntroductionThe ApoE gene (Physiological Functions)The ApoE isomersApoE AÃŽ ² Aggregation (Fibrillogenesis)AÃŽ ² Clearance by ApoE ApoE and Neuronal InflammationConclusionBibliographyRelated Introduction Research into the genetic causes of Alzheimer’s disease have progressed considerably and currently at least three different genes are known to be linked with AD pathogenesis. Of these the apolipoprotein gene E (APOE), an amino acid glycoprotein, is one of the main focus of research over the last decade or so and significant associations between one particular isoform of the gene and the onset of AD have been reported. This isomer, referred to as the ApoE 4 allele, has been implicated in AD pathogenesis while other forms of the gene the ApoE 2 and the ApoE 3 have been reported to have a protective effect against the onset of AD. Though research has confirmed this variable effect of the different forms of the ApoE gene, there is still a lack of concrete evidence as to the exact pathway and the mechanism by which ApoE 4 contributes to neurodegeneration in AD patients.   A brief review of related research would provide us more insight into the various pathological actions of Apo E 4 and how these multiple factors could lead to a gradual cognitive decline which is symptomatic in Alzheimer’s patients. The ApoE gene (Physiological Functions) ApoE is an amino acid glycoprotein that is found mainly in the liver and the brain. In the brain, ApoE is predominantly secreted by the astrocytes. Two other forms of apolipoproteins namely ApoA-1 and ApoJ are also found in the brain. In vitro studies of these two genes have so far suggested that both of them exhibit a neuroprotective effect. Both these proteins bind to AÃŽ ² and therefore are thought to reduce AÃŽ ² aggregation in the brain which is a known marker of AD.   However, in vivo studies have not replicated such results and so the protective roles of ApoA-1 and ApoJ are not yet clear.   The ApoE supports cholesterol equilibrium by serving as a ligand during endocytosis of lipoprotein particles by LDL receptors. Research is divided in the opinion that the cholesterol released from ApoE mediated endocytosis process is actually used for improving the synaptic connections or the synaptic plasticity. Mice based in vivo studies have not attested to this synaptogenesis. (Kim et.al, 2009) The ApoE isomers Three single nucleotide polymorphisms of the ApoE gene are commonly identified in humans. These are the apoE2 (cys112, cys158), apoE3 (cys112, arg158), and apoE4 (arg112, arg158) respectively. (Kim et.al, 2009) The structural and functional aspects of the three isomers of ApoE are totally altered though they differ by only one or two amino acid positions.   Studies have reported strong immune-reactivity of the human apoE4 gene on amyloid plagues and the apoE4 isomer has been associated with having a strongest risk factor for AD. Some studies such as (Bertram et al., 2007) and (Bertram et al., 2009) have attested to this role of the apoE4 isomer in AD.   Bertram et al., 2009 for instance reported that people with a single copy of the apoE4 gene had a three fold increase in risk for AD, while the   risk was 12 fold among those with a dual copy of the ApoE4 gene.   The results from studies also suggest the possible role of some environmental factors as research based on some eth nic groups have revealed that the ApoE 4 gene does not have a significant effect on AD. ApoE AÃŽ ² Aggregation (Fibrillogenesis) Several research studies have focused upon the potential role of ApoE 4 in causing AÃŽ ² aggregation and neuronal degeneration. This direct interaction between the ApoE 4 with beta amyloid is attributed in the pathogenesis of the disease. Therefore it was hypothesized that increased levels of ApoE 4 in the brain corresponded to increased formation and thickness of amyloid plaques. The findings from one comprehensive study by Tiraboschi et.al (2004) validated this hypothesis. The researchers in this study confirmed increased plaque density corresponding to increased levels of ApoE 4. This positive association was again confirmed by a more recent study by Reiman et.al (2009). The researchers of this study used an amyloid detecting agent such as Pittsburgh compound B (PIB) along with positron emission tomography to detect the levels of fibrillar AÃŽ ² in the subjects. The researchers then correlated this information among individuals with varied genetic risks. The results from the study clearly revealed that ApoE 4 homozygotes had the highest risk (91%) for developing AD while ApoE 4 heterozygotes had a moderate risk of 47% and finally ApoE 4 non carriers had only 20% risk of having AD. Furthermore, the mean age of onset of AD was also vastly different with ApoE 4 homozygotes at 64, heterozygotes at 76 and 84 years of age among non carriers.   This longitudinal study clearly provides positive evidence connecting the ApoE 4 gene with a high risk for AD.   Thus there is enough evidence that ApoE 4 gene may aid in ï ¬ brillogenesis and consequent cognitive decli ne. (Reiman et.al 2009). AÃŽ ² Clearance by ApoE Some studies have shown that ApoE by binding with soluble AÃŽ ² promotes the cellular uptake and ingestion of the ApoE –AÃŽ ² complex   Ã‚  by endocytosis.   However, isomer specific results for this ApoE facilitated cellular uptake of AÃŽ ² are still awaited.   Research has also focused on the possible clearance of   AÃŽ ² from the brain via the blood brain barrier. However, there is growing evidence that ApoE 4 might actually hinder or reduce this clearance of AÃŽ ².   Deane et.al (2008), a study based on mice reported that the clearance rate of ApoE 4 –AÃŽ ² complex is much lower than that for the ApoE2 and ApoE 3 complexes. Other recent studies such as Bell et.al (2007) and Ito et.al (2007) that focused on studying the AÃŽ ² clearance in humans found that the clearance rate along the Blood Brain Barrier (BBB) was significantly lower for the ApoE 4 –AÃŽ ² complex compared to that of simple AÃŽ ² peptides.   These studies offer enough evidence that ApoE 4 might actually increase the fibrillogenesis by directly affecting the AÃŽ ² metabolism in the brain. By reducing the clearance rate and promoting aggregation ApoE 4 gene definitely poses an increased risk factor for AD. ApoE and Neuronal Inflammation Several studies have reported that ApoE has marked anti inflammatory properties which explain the surge in their production in the aftermath of an injury. These studies hypothesize that ApoE is needed for maintaining the cholesterol homeostasis, and in particular for increasing the availability of cholesterol for neuronal repair and improving the synaptic plasticity subsequent to brain injury. (Slezak Pfriege, 2003 ). However studies have also reported differences in neurite growth and synaptic plasticity post neuronal insult in animal studies based on the genotype.   One transgenic mice study found that neuronal growth and synaptogenesis were markedly lower among ApoE 4 transgenic mice compared to ApoE3 transgenic mice. (White et.al, 2001) An extensive review of the neuroprotective effects of the various ApoE isomers by (Cambon et al, 2000) clearly showed differential effects between the isomers. Most of the studies reported that ApoE3 promoted synaptic plasticity and neurite gro wth. However similar positive results were not witnessed in the case of ApoE 4 alleles with some studies even reporting the negative effects of ApoE 4 on synaptic plasticity and neuronal growth.   Colton et.al (2004) found that the anti-inflammatory effects vary drastically between the ApoE isomers.   The researchers studied this variability in anti-inflammatory response triggered by the ApoE 3 and ApoE4 isomers by using in vivo experiment conducted on ApoE knockin mice. By studying Lipopolysaccharide (LPS) mediated inflammatory responses the researchers observed the differences between the isomers. The inflammatory response was much greater in the ApoE 4 knockin mice when compared to the ApoE3 Knockin mice. These studies suggest that the anti inflammatory response maybe less active in ApoE 4 and this might lead to neuronal damage as witnessed in AD patients.  Ã‚   (Kim et.al, 2009) Conclusion The review of studies has revealed that the ApoE isomers have differential effects on the AÃŽ ² metabolism in the brain. While the ApoE 2 and ApoE 3 isomers have been reported for their protective effects the ApoE 4 allele clearly seems to contribute to the AD pathogenesis. Results from recent fibrillar PET imaging studies suggest a clear positive correlation between the ApoE 4 allele and the density of amyloid plaque formation. It is clear that by slowing down clearance of AÃŽ ² as well as contributing to its aggregation in the brain, the ApoE 4 allele increases the susceptibility of a person for AD. It is also possible that the ApoE 4 also lowers the protective function by increasing the neuronal inflammatory response and by hindering neurite growth. More studies are necessary to understand the complex relationship between ApoE and AÃŽ ² and the levels of different isomers of ApoE and their corresponding impact on Neuroinflammation and neurotoxicity, etc. Bibliography Jungsu Kim, Jacob M. Basak, David M. Holtzman, (Aug 13th 2009), The Role of Apolipoprotein E in Alzheimer’s disease, Neuron 63. Bertram, L., McQueen, M.B., Mullin, K., Blacker, D., and Tanzi, R.E. (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39, 17–23. Bertram, L., McQueen, M.B., Mullin, K., Blacker, D., and Tanzi, R.E. (2009). The AlzGene Database Alzheimer Research Forum available at, alzgene.org. Eric M. Reiman, Kewei Chen,Xiaofen Liu et.al (Apr 2009), Fibrillar amyloid-ÃŽ ² burden in cognitively normal people at 3 levels of genetic risk for Alzheimers disease, Proc Natl Acad Sci U S A.  ;  106(16): 6820–6825. Bell, R.D., Sagare, A.P., Friedman, A.E., Bedi et.al (2007). Transport pathways for clearance of human Alzheimer’s amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab. 27, 909–918. Ito, S., Ohtsuki, S., Kamiie, J., Nezu, Y., and Terasaki, T. (2007). Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes. J. Neurochem. 103, 2482–2490 Part 2 Fibrillar amyloid-ÃŽ ² burden in cognitively normal people at 3 levels of genetic risk for Alzheimers disease   (Reiman et.al 2009) This research study by Reiman et.al (2009) hypothesized that fibrillar amyloid accumulation is an early development in the onset of Alzheimer’s disease.   The researchers further hypothesized that the fibrillar amyloid accumulation precedes any recognizable symptoms of cognitive decline. Amyloid plaques are a distinct feature of AD as observed from post mortem studies. Given the hypothesis that fibrillar AÃŽ ² accumulation is observed even in healthy, non symptomatic adults, the researchers intended to study the effect of fibrillar AÃŽ ² burden as a predictor of future onset of AD on adults with normal cognitive function using Ante mortem  brain imaging studies. For this study, the researchers used Pittsburgh Compound B (PiB), a radio ligand that binds only with the fibrillar AÃŽ ² species. Earlier studies have also used this PIB for imaging studies of live human brain to observe the formation of fibrillar AÃŽ ² in healthy adults. This study by the authors is aimed to extend the previous studies by providing a genetic risk analysis and to understand the predisposition to AD based on an individuals APOE genotype. The APOE genotypes were identified by using blood sample analysis. The researchers used fluorodeoxyglucose PET, volumetric MRI and neuropsychological tests. Fibrillar imaging was done using 3 dimensional HR+ scanner.   The subjects of this study were all cognitively normal and late middle aged people representing a mixture of APOE genotypes. This was a longitudinal study and the subjects were assessed every 2 years. The researchers observed that cerebral glucose metabolism levels of those subjects carrying dual copy of the ApoE 4 (homozygotes) was significantly lower than that of the heterozygotes and the non carriers. With the PiB Pet images the researchers compared and correlated the fibrillar burden with the genetic risk to understand the predisposition for AD between the various isomers. The average Pittsburgh(PiB) distribution volume rations(DVR), which is a measure of the fibrillar AÃŽ ² accumulation, was on increase in all the three different groups in the 2 years period. One of the homozygote subjects developed mild amnesia and her DVR was close to that of an AD patient. Overall of all the 28 subjects (8 homozygotes, 8 heterozygotes and 12 non carriers), the ROI measurements pertaining to the different brain regions such as temporal, parietal, posterior cingulate-precuneus, basal ganglia, etc, was the highest among the homozygotes. The researchers used statistical analysis and found that the homozygotes had considerably higher ROI values when compared to the non carriers (P   .05) while the difference between the heterozygotes and the non carriers was not significant (.05   P   .11). When correlated the APOE4 and Fibrillar AÃŽ ² burden was found to be significant among both homozygotes and heterozygotes compared with the non carriers. The study authors successfully found that even in cognitively normal individuals there is a positive correlation between ApoE 4 and fibrillar AÃŽ ². The results from the study suggest that the ApoE 4 is clearly associated with increased AÃŽ ² aggregation and decreased AÃŽ ² clearance. The following PET map clearly indicates the various regions of the brain that are affected by AÃŽ ² accumulation. Group A represents the homozygotes while group B and C represent the heterozygotes and non carriers respectively. Longitudinal studies are very effective in following the growth of fibrillar AÃŽ ² accumulation as they provide a clear pattern of disease progression even in the asymptomatic stage. People who are in late middle age who are at risk for AD would greatly benefit from a prophylactic intervention based on the brain mapping study and their ApoE genotype. This study clearly contributes to our understanding that the ApoE 4 is directly involved in the AÃŽ ² interaction and the formation of Amyloid Plaques. By considering live brain images for the study the authors were able to clearly confirm the association between the ApoE 4 and AÃŽ ² fibrillar density and predict the increased susceptibility of people with that genotype. This study has large implications for the treatment of AD. By proving that AÃŽ ² fibrillar formation precedes a perceivable cognitive decline, this study recommends early interventions particularly for people with ApoE 4 genotype, as the current AÃŽ ² modifying treatments would be more effective before extensive AÃŽ ² accumulation has occurred. The researchers advocate the use of brain imaging studies combined with genotype based risk assessment as a potentially powerful tool in preventive therapy for people who are at a genetically high risk for AD. One of the drawbacks of the study is the very small study sample. A large cohort based longitudinal study would have provided more conclusive confirmation of the study results. Bibliography Eric M. Reiman, Kewei Chen,Xiaofen Liu et.al (Apr 2009), Fibrillar amyloid-ÃŽ ² burden in cognitively normal people at 3 levels of genetic risk for Alzheimers disease, Proc Natl Acad Sci U S A.  ;  106(16): 6820–6825.

Friday, November 22, 2019

Business and Management Free-Sample for Students-Myassignmenthelp

Business and management are interrelated with each other. Application of effective management techniques assists the personnel of panies and organizations to carry out the business activities efficiently. For the achievement of efficiency in business activities, raw materials are a crucial factor (Gollenia, 2016). Within this, adherence to the integrated structure helps the personnel to create and develop effective plans. Involvement of the employees, stakeholders and shareholders within this process helps the personnel to ensure the effectiveness and feasibility of the proposed plans in terms of the identified and the specified requirements. Maintenance of consistency in the execution of evaluation brings to the forefront the potential drawbacks in the products and services. Exposure of spontaneity in rectification of the drawbacks reflects the corporate attitude of the personnel (Weske, 2012). Herein, lays the true essence of the aspect of management . All these aspects seem tru e for Westfarmers. Theoretical framework provides a clearer understanding about the basic concepts related to the management of business activities. One of these theories is the contingency theory, which pels the managers to put on their thinking caps in terms of taking decisions for the betterment of the panies and organizations (Fadun, 2013). Maintaining pace with the current trends is an important proposition of this theory. This alignment helps the personnel of Westfarmers to maintain their position within the Australian market. Involvement of the employees, stakeholders, shareholders and agency partners in the decision-making process proves beneficial for Westfarmers in ensuring the effectiveness of the proposed plans in terms of the identified and specified requirements (Wong et al., 2014). Along with the contingency theory, systems theory proves beneficial for Westfarmers in terms of achieving successful pletion of the business activities. Viewing it from other perspectives, systems theory helps the personnel of Westfarmers to ensure the presence of defects within the devices. This reflects the consciousness of the personnel towards bestowing productive energy to the buyers. Hiring experts for detecting the presence of virus attacks or hacking interventions is an indication of effective utilization of systems theory by the Westfarmers personnel. Delving deep into the functionality of Westfarmers, for the production of efficient and productive energy, technologically advanced machines are required (Zhang & Wang, 2012). Negligence in this direction deprives the Westfarmers personnel from getting uninterrupted current flow for manufacturing efficient energy resources. This negligence is also an obstacle in terms of ensuring the smooth functioning of the internal parts of the devices. On the contrary, market research in terms of getting the advanced machines. However, ensuring financial flexibility is crucial for adopting mahines, whih aligns with the modern tehnology (Jeston & Nelis, 2014). Evaluation of the seleted device helps the personnel to ensure the effectiveness and applicability of the selected device in terms of the identified and specified requirements. Maintenance of consistency in the execution of evaluation brings noticeable improvements in the performance of Westfarmers. Exposure of consistency towards the evaluation upgrades the status of the Westfarmers in terms of enjoying petitive advantage over the contemporary brands. One of the noticeable facts within this is the adherence and pliance to the petitive policies, which helps the Westfarmers personnel to indulge into fair trades, transactions and deals with the contemporary brands (Fleischmann et al., 2014). The â€Å"fairness† in the earlier sentence aligns with the factor of quality, which is one of the major factors for attaining customer satisfaction. In order to manage the business activities, Westfarmers personnel abide by an integrated structure. As a matter of specification, within the management e ponents, such as sales, operations, finance and human resource management. Finance is an agent, which aters to the effective management of sales operations and human resource management. Flexibility in the financial aspect helps the Westfarmer personnel to introduce prospective schemes, offers and discounts for the buyers. Simultaneously with the success, failures also find its way. Countering this, emerging successful in ove ing the failures, qualifies Westfarmers as leader within the brands struggling for a firm place in the petitive market of Australia (Becker, Kugeler & Rosemann, 2013). The effective coordination between the functional units of the departments is the keystone towards managing the crisis period. The major drive behind this is the pliance to the risk assessment process, which is assistance towards reducing the i ntensity of the potential risk factors. Identification of the risks and their causes solves half of the problem. Application of known solutions further eases out the process of risk assessment. In case of failures, application of alternate solutions reflects the conscious attitude of the Westfarmer personnel in terms of ensuring the wellbeing of the customers (Weiss, 2014). Along with this, rating the risks projects the confidence of the personnel towards reducing the intensity of the risk factors. Emerging successful in this direction adds value to the roles and responsibilities of the managers. Involvement of the employees, stakeholders, shareholders and agency partners in this risk assessment process helps the organizational personnel in terms of ensuring the effectiveness of the implemented solution for carrying out the business activities (Rosemann & Brocke, 2015). Herein, lays the conjoined significance of business and management. Adherence and pliance to the risk assessment p rocess is an additional assistance in terms of reducing the instances of harassments, discriminations, conflicts among others. Apart from risk assessment, training forms an important ponent for Westfarmers personnel in terms of managing the business activities. Frequent training programs improve the grasping power of the employees on the basic management skills. Providing training to the employees on the operation of the devices brings efficiency in the business activities of the organization. Taking post-training tests enables the managers to test the capability of the employees to make practical application of the learnt skills in the workplace operations (Dumas et al., 2013). Moreover, trainings also prove essential in handling the emergency situations in an effective manner. Provision of adequate motivation and encouragement by the managers generates an urge among the employees to expose better performance. Maintenance of consistency from both sides in this context results in the exposure of professional performance of the Westfarmers personnel. Conscious attitude towards the reduction of carbon and smoke emission enhances the corporate social responsibilities of the organization (Chang, 2016). As a matter of specification, boycotting the utilization of carbon footprints in the manufacture of the energy resources proves advantageous for the organization, Westfarmers in mitigating the health hazards of the customers. This action expands the reputational status of the organization into a widespread one. Exposure of consciousness in this direction uplifts the corporate attitude of the personnel. This results in the establishment of professionalism in the workplace of the organization (Hutt & Speh, 2012). Provision of safe and fortable workplace to the employees results in the outpour of creative output, which takes the organization, Westfarmers to achieve high growth rate and a sound profit margin. Adoption of social media helps the organization, Westfarmers to expand the business. Putting the news of the newly launched devices makes the investors aware of the organizational issues. The means of social media supports the organization to increase the trafficking of the audience towards the brand image (Aalst, 2013). Levying authentic information to the customers, agency partners enhances the brand awareness of the organization. One of the noticeable features about Westfarmers is the effective management of human resources. Provision of training on the effective and judicious utilization of the organizational resources adds efficiency in the business activities. Viewing it from other perspective, this efficiency contradicts the issues of inadequate stock of raw materials. Attaching the concept of soial media here, advertising authentic information about the recruitment process systematizes the management of human resources (Rà ¶glinger, Pà ¶ppelbuß & Becker, 2012). Herein, management and business can be placed in an equal alignment, which establishes relevancy with the requirements of the discussion. Emerging successful in ove ing the challenges attains a different connotation towards management. Herein, the statement, â€Å"Failures are the stepping stones of success†, b es tautologically true. Dedication and mitment towards upgrading the services adds color to the steps, which leads to the path of success. On the contrary, negligence in this direction aggravates the hardness of the stones, which detach the organization from the identified and specified business requirements (Hutt & Speh, 2012). Herein, lays the interplay with the phases of success and failure of the organization, which adds value to the discussion. On the other hand, this interplay can be aligned with the organizational capability to restore lost glory and honor within the petitive ambience of the market. Different parameters of management helps Westfarmers broaden the perspectives of the managers. Risk assessment brings to the forefront the areas on which training needs to be delivered to the employees.   Effective and judicious utilization of the provided training adds efficiency in the business activities of the organization (Chang, 2016). Within this, utilization of the means, such as, social media acts as a promotional activity for the organization in terms of achieving large scale ustomer satisfaction. Specifically, execution of marketing mix supports the organization to align with their mission, vision and core values. Consciousness of the personnel in this direction adds to the organizational culture, which provides a better placement to the organization within the Australian market. Becker, J., Kugeler, M., & Rosemann, M. (Eds.). (2013).  Process management: a guide for the design of business processes. Springer Science & Business Media. Chang, J. F. (2016).  Business process management systems: strategy and implementation. CRC Press. Dumas, M., La Rosa, M., Mendling, J., & Reijers, H. A. (2013).  Fundamentals of business process management  (Vol. 1, p. 2). Heidelberg: Springer. Fadun, O. S. (2013). Risk management and risk management failure: Lessons for business enterprises.  International Journal of Academic Research in Business and Social Sciences,  3(2), 225. Fleischmann, A., Schmidt, W., Stary, C., Obermeier, S., & Brger, E. (2014).  Subject-oriented business process management. Springer Publishing pany, Incorporated. Gollenia, L. A. (2016).  Business Transformation Management Methodology. Routledge. Hutt, M. D., & Speh, T. W. (2012).  Business marketing management: B2B. Cengage Learning. Jeston, J., & Nelis, J. (2014).  Business process management. Routledge. Rà ¶glinger, M., Pà ¶ppelbuß, J., & Becker, J. (2012). Maturity models in business process management.  Business Process Management Journal,  18(2), 328-346. Rosemann, M., & vom Brocke, J. (2015). The six core elements of business process management. In  Handbook on business process management 1  (pp. 105-122). Springer Berlin Heidelberg. Van Der Aalst, W. M. (2013). Business process management: a prehensive survey.  ISRN Software Engineering,  2013. Weiss, J. W. (2014).  Business ethics: A stakeholder and issues management approach. Berrett-Koehler Publishers. Weske, M. (2012). Business process management architectures. In  Business Process Management  (pp. 333-371). Springer Berlin Heidelberg. Wong, W. P., Tseng, M. L., & Tan, K. H. (2014). A business process management capabilities perspective on organisation performance.  Total Quality Management & Business Excellence,  25(5-6), 602-617. Zhang, P., & Wang, C. (2012). The evolution of social merce: an examination from the people, business, technology, and information perspective.

Wednesday, November 20, 2019

Reflexive Managers in Contemporary Organisations Term Paper

Reflexive Managers in Contemporary Organisations - Term Paper Example Every manager has to realize that there is dual responsibility associated with this position as the individual has to both accomplish the organizational objectives and provide guidance to the subordinates in giving their best efforts. Moreover, the managers have to perform their self-assessment to review their own set of competencies and make sure that they possess the proficiencies required for assisting the subordinates or employees in contributing effectively within the enterprises (Cunliffe, 2013). In order to provide appropriate resources to the managers, the theorists of the organizational management field have stressed the need for utilizing the reflection process within their job responsibilities. In the present era, everyone has to act as a reflexive individual who continuously and critically thinks about the way an action is taken by the person. This analysis will allow the individual to assess the act from various perspectives so that he/she can review the perception held by the person and how others will perceive it (Bradbury, 2010; Gunia et al., 2012). Also, most of the contemporary organizations are supporting the designing and implementation of the training programs for the management positions in which managers are given adequate training for becoming the reflexive practitioners or reflexive managers (Broussine & Ahmed, 2013). The overall aim of such training sessions is to develop the critical thinking and self-assessment techniques in the managers so that they can reflect upon their own course of actions and be assured that a positive, complying and appropriate perception is created in the minds of the subordinates (Bolton, 2010). Moreover, it is stated by Hibbert (2012) that reflexive manager is mandatory for the modern day organizations as the expert has to critically evaluate his/her own practices at three instances i.e. before, during and after the decision/action.  

Monday, November 18, 2019

Nissan Essay Example | Topics and Well Written Essays - 2250 words

Nissan - Essay Example These cars were developed first in the late 1960s and have continued to be modified to adapt to the changing the changing trends to date. On the other hand, there is the Nissan Patrol is a suburban utility vehicle (SUV) that was developed around 1951 to compete with car brands such as Toyota’s Land Cruiser. This car has been advanced over the generations and currently it is in its sixth generation, which began in 2010. The Patrol occurs has a four-wheel drive and is available in either short-wheelbase with three doors or long-wheelbase with five door chassis. Both cars come in a variety of models that have continued to attract customers due to the continued development. The development of Nissan Skyline GT-R brand has a long history that is linked to the previous products developed by Nissan. Prince Automobile Company was the first company to use the word ‘Skyline’- they developed sedan cars that fell on a line of Skyline products. However, after the merger with Nissan-Datsun, it adopted the Skyline series of cars. Skyline cars were developed with rear wheel drive, an aspect that continued to the 1990s when other manufacturers started focusing on shifting the drive to the front wheels. The adoption of the GT-R cars for racing purposes made them to have direct market while at other instances some of the versions such as the KPGC110 2000 GT-R made very little sales, a situation that was attributed to a looming energy crisis at the time. Just before the development of Nissan Skyline GT-R, there was the S54 2000 GT-B that was a powerful racecar at the time. The GT-R series saw the development of PGC10 2000 GT-R, which made very impressive wins over a period of almost two years. There were a number of racing victories that were associated with this particular car from 1964 to the time it was discontinued in 1972. The Nissan Motorsport (Nismo) has been on the forefront of developing this car to

Saturday, November 16, 2019

The aim of ISIS Essay Example for Free

The aim of ISIS Essay I known as Islamic State in Iraq and the Levant and Islamic State. The aim of ISIS is to create an Islamic state across Sunni areas of Iraq and in Syria. ISIS is known for killing dozens of people at a time and carrying out public executions and crucifixions. It has taken over large swaths of northern and western Iraq. The group currently controls hundreds of miles. It ignores international borders and has a presence from Syrias Mediterranean coast to south of Baghdad. It rules by Sharia law. Unable to serve under the new Iraq government after Saddam Husseins military was disbanded, former Iraqi soldiers became ISIS fighters. ISIS took Baquba, Iraq, as its capital and swore allegiance to Abu Omar al-Baghdadi as the group’s emir. Baghdadi’s real name is Hamed Dawood Mohammed Khalil al-Zawi; he was born in 1959. He used to work in the Iraqi security corps, then left after he embraced Salafist ideology in 1985. He was one of the most prominent promoters of Salafist ideology. He was made head of Jaish al-Taefa al-Mansoura then swore allegiance to al-Qaeda in Mesopotamia, which later formed, with other groups, the Mujahedeen Shura Council in Iraq. The leader called for attacks in the United States and France two countries that have been conducting airstrikes against ISIS in Iraq. The leader gave specifics on how to attack Westerners: Rig the roads with explosives for them. Attack their bases. Raid their homes. Cut off their heads. Do not let them feel secure. Hunt them wherever they may be. Turn their worldly life into fear and fire. Remove their families from their homes and thereafter blow up their homes. Al Qaeda has called for similar attacks in the past. But given ISIS radical support base, which believes ISIS leaders are the rightful sovereign leaders of all Muslims worldwide, the ISIS pronouncement carries more weight. There are two new elements in this policy, First, air strikes will not be restricted to areas where ISIS poses a threat to the U.S. Instead, they can strafe and bomb ISIS targets anywhere in Iraq, coordinating the strikes with assaults on the ground by Iraqi soldiers, militias, or Kurdish peshmerga. Second, these air strikes will take out ISIS jihadists not only in Iraq but also across the border in Syria. A senior official stressed that this part of the policy is not as open-ended as the speech makes it seem. Obama is  well aware that air strikes alone don’t produce victory. They need to be synchronized with ground assaults. And for now, there are no ground forces in Syria that can beat back ISIS. There are two big new elements in this policy: First, air strikes will no longer be restricted to areas where ISIS poses a threat to U.S. personnel. Instead, they can strafe and bomb ISIS targets anywhere in Iraq, coordinating the strikes with assaults on the ground by Iraqi soldiers, militias, or Kurdish peshmerga. Second, these air strikes will take out ISIS jihadists not only in Iraq but also across the border in Syria. A senior official stressed that this part of the policy is not as open-ended as the speech makes it seem. Obama is well aware that air strikes alone don’t produce victory. They need to be synchronized with ground assaults. And for now, there are no ground forces in Syria that can beat back ISIS.

Thursday, November 14, 2019

Friendship in Dandelion Wine :: essays research papers

Friendship in Dandelion Wine How important is friendship in the lives of teenagers today? In the book Dandelion Wine friendship is one of the main and supporting themes that intertwines throughout the book. Friendship can come in all shapes and sizes, but when you lose a friend there are many affects. People can't imagine surviving high school and adolescence without their friends. John the best friend of Doug moves away, the aspects of losing his best friend were devastating bringing a turning point in to Doug's life with many affects. It was a sunny day until a sudden cloud came over Doug’s head, when the reality of John moving hit him (Bradbury 103) “John took the yellow and green train ticket solemnly from his pocket and they both looked at it'; (Bradbury 103). With this type of situation kids are forced to make decisions to cope with the environment around them. “Whether they’re gossiping on the telephone or huddled in school hallways, teen-agers are constantly reaching out to their friends. They can’t imagine surviving high school and adolescence without them.'; The very word of friendship is complicated in the world today. When someone leaves you for any reason you are going to miss him or her with many affects. As memories flow through your head remembering the person that left seems to get harder and harder. In the book Dandelion Wine John started to notice little things that he never noticed before, and this scared him for he was afraid that Doug wouldn’t remember him. & #8220;Shut your eyes, Doug. Now, tell me, what color eyes I got? Don’t peek. What color eyes I got?'; Douglas began to sweat. His eyelids twitched nervously. Aw heck, John that’s not fair. Tell me. Brown! John turned away. No sir. What you mean, no? You’re not even close!'; John closed his eyes. Turn around here, said Douglas. “Open up, let me see. It’s no use, said John. You’re forgot already. Just the way I said. Turn around here! Douglas grabbed him by the hair and turned him slowly. Okay Doug. John opened his eyes. Green.'; (Bradbury 105-106). The very sentimental aspect of these affects can help to shape yourself by the environment around you. “Maintaining friendship can cause a lot of anxiety among teens. One of the biggest issues is trust. Confiding in people can be tricky, a betrayal of a confidence can break a friendship'; (Ellis H1+).

Monday, November 11, 2019

“Neat People vs Sloppy People” analysis Essay

â€Å"Neat People vs. Sloppy People†, by Suzanne Britt compares the day-to-day life and habits of â€Å"sloppy† people to notorious â€Å"neat† people. Britt’s point of view leans towards the sloppy person, causing the reader to conclude that the author is most likely sloppy in her own life. The meanings of the adjectives â€Å"neat† and â€Å"sloppy† seem to be flipped around when defined and exemplified. Someone reading this article is either going to be bothered by the context or is going to agree with the view of the messy side. The author’s hope is probably for others to appreciate the morals and intentions of the two different types of people. Read more: Good people short story  essay The author of this essay, Suzanne Britt is a poet, essayist, and teacher. Her essay â€Å"Neat People vs. Sloppy People† is from one of her books â€Å"Show and Tell†. The purpose of her essay is to highlight the differences of neat people and sloppy people by changing the meaning and purposes around this topic. The tone of her essay is humorous, yet straightforward. She is able to make jokes about both sides, while being assertive in her meaning of these two styles of life. Through contrasting the two types of people in this essay, Britt is able to convey her purpose of recognizing neat people as â€Å"lazier and meaner than sloppy people†(para. 1). She also states that â€Å"sloppy people live in Never-Never Land† because they never get anything done, since they depend on â€Å"someday† to get their task accomplished (para. 3). By looking at these two contrasting lifestyles, it is seems that she favors the sloppy side of life. Even though she talk s about the sloppy life as putting things off and collecting clutter, she recognizes it as a good thing. It is as though she switches the meanings of the two characteristics to make sloppy positive and neat negative, showing the author has a preference. This odd exchange of the two types of traits makes this article interesting since most would associate being sloppy as a negative. When analyzing these two traits it is seems that the characteristics that would normally describe a neat person describes a sloppy person. When stating, â€Å"neat people are bums and clods at heart†, the author uses derogative words to describe the person (para. 6). The term â€Å"neat† usually means organized and put together, which is what she means by the term â€Å"sloppy†. Sloppy people are stated to â€Å"give loving attention to every detail. When sloppy  people say they’re going to tackle the surface of the desk, they really mean it.† Britt makes the neat peop le seem bothersome and uncaring, while the sloppy people seem determined and nurturing. As stated previously, the term â€Å"someday† is used repetitively in the second paragraph to describe when the goals of a sloppy person will be made. It is evident that sloppy people never get anything accomplished in their lives, because they are held back by the word â€Å"someday†. However, the author seems to think someday is not always a bad thing. Britt states â€Å"sloppy people can’t bear to part with anything†, which creates the sense of possible hoarding problems by sloppy people. They never know when they just might need something and it would be a waste to have to rebuy something that they had previously. So, I guess she thinks that they are thrifty and not wasteful people. Neat people get rid of things too quick and can be uneconomical in the long run. This essay â€Å"Neat People vs. Sloppy People† analyzes two opposite lifestyles. By switching their meanings around, Britt is able to show just how different these two lifestyles are. She seems to imply that sloppy people are caring and will get to things done when needed. They are laid back and want to enjoy life by not worrying about keeping everything perfect. Sloppy people do not get caught up in the day to day rush of life and enjoy what they do. Neat people are not relaxed and worry about what others think too much. The author seems to feel that there is more to life than being spick-and-span. One can insinuate based on how she describes both neat and sloppy that Britt favors the messy side. The purpose of her essay is to convey how different each lifestyle is and how they can’t be one without the other. She uses humor almost in a satirical way in order to get her point across while being completely forward with the reader in her feelings towards both sides. By i ncorporating different techniques throughout her essay, Britt is able to portray her thoughts and feelings on the subject of neat verses sloppy people. After reading her article, a neat person might consider relaxing a bit and recognize that there just might be more to life than being spotless.

Saturday, November 9, 2019

Argumentative Synthesis

In Mr. Siemiesz’s chapter he explained about the National Security Consequences of U. S Oil Dependence and how it could be fixed and changed for the best interest of the country; Mr. Siemiesz outlined specific points or steps the country could take to make those changes he outlined in the chapter. â€Å"Those major energy suppliers from Russia to Iraq to Venezuela have been increasingly able and willing to use their resources to pressure their strategic and political objectives.That these country’s are consuming less oil less then all of the other countries especially the United States. The Fact is that the U. S. makes up to 4. 6% of the world’s population but uses 25% of the world’s oil. So the challenge of this is over the next several years the U. S. needs to slow down and stop consuming a lot of Oil and hopefully find new ways to find energy†. In Mr. Franco’s chapter â€Å"205 ways to save the Earth† explains several ways to save t he planet; the author of the chapter Thomas L. Friedman speaks in his article about the word â€Å"Green† and how that term is used, he continued in the article to say that people need to find ways to improve the environment and recommended that it is in the best interest of the world to preserve the world he goes into ways for example like citizens of the world should being recycling and to help beautify the planet.Mr. Franco’s chapter concludes that the countries of the world have to learn better ways to improve the environment for everyone. The basic proposition behind the science of climate change is so firmly rooted in the laws of physics that no reasonable person can dispute it. All other things being equal, adding carbon dioxide (CO2) to the atmosphere—by, for example, burning millions of tons of oil, coal and natural gas—will make it warm up. That, as the Nobel Prize–winning chemist Svante Arrhenius first explained in 1896, is because CO2 i s relatively transparent to visible light from the sun, which heats the planet during the day.But it is relatively opaque to infrared, which the earth tries to reradiate back into space at night. If the planet were a featureless, monochromatic billiard ball without mountains, oceans, vegetation and polar ice caps, a steadily rising concentration of CO2 would mean a steadily warming earth†. The earth’s temperature can go up and destroy the polar ice caps and kills a lot of fish and raise the water and flood states. Crops are going to dry out so we can’t eat anything.People are taking advantage of it and destroying our planet. â€Å"The Greenhouse Effect is also comparing to global warming that it is a process by which thermal radiation from a planetary surface is absorbed by atmospheric greenhouse gases and is re-radiated in all directions. Since part of this re-radiation is back towards the surface, energy is transferred to the surface and the lower atmosphereâ € . As a result, the temperature there is higher than it would be if direct heating by solar radiation were the only warming mechanism.Global warming of the Earth's surface and lower atmosphere is believed to be the result of a strengthening of the greenhouse effect mostly due to human-produced increases in atmospheric greenhouse gases by which thermal radiation from a planetary surface is absorbed by atmospheric greenhouse gases and is re-radiated in all directions. Since part of this re-radiation is back towards the surface, energy is transferred to the surface and the lower atmosphere. In Mr. Anderson’s chapter explains to the reader how Oil is critical to the U. S. Economy and how their aren’t any viable alternatives that the author believes will set the United States on the path to energy independence; The Author Price continued to say that â€Å"politicians and environmentalist misled Americans about the realities of energy which lead to legislation that hurt s America in the global marketplace† Price believes that they truly don’t understand what is going on when it comes to the environment and he continued saying that is why the United States is so dependable on foreign oil.Mr. Anderson’s chapter concludes with the following â€Å"price admits American imports of crude are high but sees no feasible alternative. The demand for energy in America is simply great and oil is simply to important for the economy†.

Thursday, November 7, 2019

Stalingrad was one of the most horrendous battles of World

Stalingrad was one of the most horrendous battles of World Stalingrad was one of the most horrendous battles of World War II. It was fought from August 1942 to February 1943, and approximately 1.5 million troops and civilians lost their lives in the battle. The Battle of Stalingrad was fought in and around the city of Stalingrad, Russia. It was a turning point in the war not only because it destroyed a major part of the German Army, but it also caused Germany to lose the initiative in battle, which it never regained. Nazi commanders, including Hitler, made numerous mistakes that allowed the Russians to take control of the battle. Although the Russian Red Army was very determined and heroic in their efforts, the battle was not theirs to win. German superiority in manpower, training, tanks, in the air, and guns should have added up to an easy German victory. As the Red Army was pouring men into Stalingrad, superior German troops and tactics resulted in ten Russians dying for every one German in Stalingrad.Paulus (left), and his aides Lt.-Gen. Arthur Schmi...

Monday, November 4, 2019

Essay Questions Example | Topics and Well Written Essays - 2000 words - 1

Questions - Essay Example For example, in deductive explanation, if God is good, and murder is bad, then murders are not Godly. A probabilistic explanation example is that if it rains every 3 days a week in June, it is likely that June will have only 10 rainy days. 4. The aims of science are to generate knowledge, allow critique, analysis and explanation of claims of a body of knowledge. Science also aims to encourage logical predictions and understanding of phenomena. 5. In prediction, knowledge is sought based on previous trends. Unlike explanation, prediction does not delve into systematic analysis of precedent factors that affect the process of body of knowledge. That way, it is reverse process of explanation. 6. In Verstehen tradition claims that the understanding of social sciences must be analyzed through the prism of human behavior subjectively. On the other hand, predictive understanding argues that logical conclusions can be drawn objectively without approach social study subjectively. 7. In order for knowledge in general and scientific methodology to be intersubjective, there has to be transmissibility between the two approaches used in gaining knowledge. That is to mean that either can inform the other owing to an assumption that their methodology remains irreproachable, e.g. both being self-critical and highly analytical so that their conclusions are reliable. 8. What the authors term â€Å"scientific revolution† is a paradigm that transforms developments abruptly rather than gradually, ideas that related to normal science. Such paradigm transforms the existing body of knowledge. 9. Kuhn’s descriptive view of science is that a rival paradigm that introduces transformation is the dominant one whereas Popper’s prescriptive theory suggests that all paradigms should be acceptable as equal without assigning them superiority statuses. 2. Conceptual definitions are those whose major aim is to

Saturday, November 2, 2019

Memo to CIO on Success Criteria for Enterprise System Implementation Case Study

Memo to CIO on Success Criteria for Enterprise System Implementation - Case Study Example The modern design may be contrived in power ranges up to 800 horsepower. Due to Environmental trends globally, demand for the new generator and motor designs have been on the rise. The company has also opened up other branches which see the need to have all of its system synchronized into one system that can make it easier for the management to consolidate most of its CRM centrally at one point. Teamwork and composition are vital in the entire CRM life cycle. The CRM team should comprise of the best individuals from the company (Brown, and Vessey, 1999). Coming up with a cross-functional team is also necessary. The team should consist of knowledgeable consultants and some internal staff such the internal staff may develop the needed technical skills required for design and implementation. The support of top management is required in the entire implementation process. The project must have a valid approval from the top management and align with critical business goals (Buckhout Frey and Nemec, 1999). This may be achieved through tying the management bonuses to the success of the project. Managers are supposed to legitimize new objectives and goals. A joint vision of the company and the function of the new CRM application and structure should be communicated directly to the employees. New structures, responsibilities, and roles of the company should be adopted. Policies should be put by top management to form modern systems in the company. There should be a clearly outlined business plan and a vision in order to steer the direction of CRM implementation. This business plan should clearly define the intended tangible and strategic merits, costs, Timeline, risk, and resources. This will assist in evaluating the extent to which the implementation process has gone and the benefits of the CRM (Callaway, 2000).